Two separate journal articles, published simultaneously in Nature and Science, detail the research from the laboratory of Warner C. Greene, MD, PhD, who directs virology and immunology research at Gladstone, an independent biomedical-research non-profit. His laboratory’s science paper reveals how, during an HIV infection, a protein known as IFI16 senses fragments of HIV DNA in abortively infected immune cells. This triggers the activation of the human enzyme caspase-1 and leads to pyroptosis, a fiery and highly inflammatory form of cell death. As revealed in the Nature paper, this repetitive cycle of abortive infection,
cell death, inflammation and recruitment of additional CD4 T cells to the infection “hot zone” ultimately destroys the immune system and causes AIDS. The Nature paper further describes laboratory tests in which an existing anti-inflammatory inhibits caspase-1, thereby preventing pyroptosis and breaking the cycle of cell death and inflammation.
“Gladstone has made two important discoveries, first by showing how the body’s own immune response to HIV causes CD4 T cell death via a pathway triggering inflammation, and secondly by identifying the host DNA sensor that detects the viral DNA and triggers this death response,” said Robert F. Siliciano, MD, PhD, a professor of Medicine at Johns Hopkins University, and a Howard Hughes Medical Institute investigator. “This one-two punch of discoveries underscores the critical value of basic science — by uncovering the major cause of CD4 T cell depletion in AIDS. Dr Greene’s laboratory has been able to identify a potential new therapy for blocking the disease’s progression and improving on current antiretroviral medications.”
http://www.tundeola.com/2013/12/anti-aids-wonder-drug-discovered.html
| Posted: at | |
TRENDING GISTS 
LOVELY; Couple Dancing On Their Wedding Day Alongside Throwback Video Of Them Dancing Together
VIDEO: 'I'm Tired Over The 'Shege' Adulthood Is Showing Me' - Comedian, Maraji Laments
CJN to Get Jumbo Pay Pack as Reps Pass Bill Increasing Salaries of Judicial Officers
BBNaija's Winner Illebaye Clocks 23 in Style, Shares New Photos
Lady Left Heartbroken After Her Husband Used N11m From Their Joint Account to Buy Wedding Ring
Actor Gabriel Afolayan Shares Loved-up Photos With Wife