Wednesday (27/09/2017)
20:45 (WAT)
Pep Guardiola's side are already guaranteed to top Group F, after beating Feyenoord 1-0 last time out, and could become the seventh side to win all six of their group matches in the competition, with Real Madrid the last side to do so in the 2014/15 campaign.
For their opponents, a draw would guarantee Shakhtar a place in the round of 16 and even a defeat would be enough for the Ukrainian side provided Napoli don't beat Feyenoord.
However, none of Shakhtar's last 12 games have ended in a draw (W4 L8), and they have kept only one clean sheet in that period.
Team news
Kevin De Bruyne is suspended after collecting three bookings while David Silva, who is not fully fit, has also stayed at home.
John Stones and Benjamin Mendy are both injured but youngsters Phil Foden, Brahim Diaz, Tosin Adarabioyo and goalkeeper Danny Grimshaw have been included.
Taison and Bohdan Butko are both injury doubts for Shakhtar.
Opta stats
This is the second competitive encounter between Shakhtar Donetsk and Manchester City after the English team's 2-0 win at the Etihad in September.
This is Manchester City's seventh consecutive Champions League participation. They have made it past the round of 16 only once, it was in 2015/16 when they reached the semi-finals (knocked out by Real Madrid).
Meanwhile, Shakhtar Donetsk have reached the knockout stages in three of their last six Champions League campaigns, their best performance dating back to 2010/11 (quarter-finalists).
Shakhtar have won their two home games in the Champions League so far this season, scoring also 2 goals in each of their last four outings on home soil.
Manchester City's 13 goals in the Champions League this season have either been scored in open play ( or from a corner kick (5, the most in 2017/18).
Raheem Sterling has scored four goals in five Champions League appearances this season, already his most prolific campaign to date.
This will be Pep Guardiola's 100th Champions League game as manager, becoming the sixth to reach that landmark after Sir Alex Ferguson, Arsene Wenger, Carlo Ancelotti, Jose Mourinho and Mircea Lucescu. He's won 61, drawn 23 and lost 15 of his previous 99 games, lifting the trophy on two occasions with Barcelona (2009, 2011).
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