Angry mobs battled each other with Molotov cocktails, rocks and sticks outside the presidential palace complex.
On Thursday, witnesses told Reuters that there also appeared to be at least four tanks outside the palace and Egypt State Radio said that two armored personnel carriers had been deployed in a nearby area called Roxy in an attempt to separate the two sides.
Quoting the Ministry of Health, state radio said five had died and 446 had been injured in the fighting.
The street battles were the worst violence since Egypt's latest crisis erupted on Nov. 22, when Morsi assumed near absolute powers.
The large scale and intensity of the fighting marked a milestone in Egypt's rapidly emerging schism, pitting the Muslim Brotherhood and ultra-conservative Islamists in one camp, against liberals, leftists and Christians in the other.
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