Time: 9:00pm
Stadium: Etihad
Referee: Clement Turpin (France)
Goal Scorer:
35', 38' Sergio Aguero,42' Leroy Sane, 56' Raheem Sterling, 69' Bernardo Silva, 78' Phil Foden, 84' Gabriel Jesus
Team News:
Guardiola made two changes to his side between the wins over Bournemouth and Watford, bringing in Vincent Kompany and Riyad Mahrez for injured pair John Stones and Kevin De Bruyne.
Stones and De Bruyne are expected to remain absent for Tuesday's visit of Schalke, while key midfield man Fernandinho is also nursing a muscle injury, but Fabian Delph may return from illness to give Oleksandr Zinchenko a rest.
With Otamendi suspended because of his red card in the first leg, and Stones unlikely to be rushed back, Kompany should retain his place in the heart of defence alongside Aymeric Laporte, who has played just 45 minutes of football since the reverse fixture.
Sane and Gabriel Jesus started the Watford match on the bench and are both in contention to return here, though it is unlikely to come at the expense of Aguero, even if the Argentine striker is in need of a rest.
Schalke will be without key man Daniele Caligiuri, meanwhile, as the playmaker picked up a leg injury last week that will rule him out for around a month.
Alessandro Schopf is also on the sidelines, so Weston McKennie is in line for a start on the right-hand side, with Hamza Mendyl on the opposite flank.
Elsewhere, Benjamin Stambouli is in contention to replace Jeffrey Bruma and Omar Mascarell's inclusion is touch-and-go as he requires a late fitness test.
Former Man City man Rabbi Matondo is also part of Schalke's travelling party.
Manchester City possible starting lineup:
Ederson; Walker, Kompany, Laporte, Zinchenko; Bernardo, Gundogan, David Silva; Sane, Aguero, Sterling
Schalke possible starting lineup:
Fahrmann; Stambouli, Sane, Nastasic; McKennie, Serdar, Bentaleb, Mendyl; Embolo, Skrzybski; Burgstaller
Head To Head
Man City have won each of their last three meetings with Schalke in European competition, including a 5-1 win in the 1969-70 Cup Winners' Cup semi-final in their only previous home meeting with the German club.
The Citizens have lost only one of their previous 10 home games against German opposition in all European competitions - a 3-1 reverse in the 2013-14 Champions League group stage against Bayern Munich.
Schalke, by comparison, are without a win in their last six games against English sides since a 2-0 victory at Arsenal in October 2012, which is their sole victory in England.
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