Jurgen Klopp has confirmed Naby Keita and Jordan Henderson will not feature on Wednesday night.
Keita returned from international duty injured, while Henderson suffered a hamstring problem against Huddersfield. Fabinho and Adam Lallana will push for a starting berth in central midfield as a result.
Sadio Mane required hand surgery after the international break and missed the 1-0 win over Huddersfield on Saturday but has declared himself fit to play for Liverpool.
James Milner and Georginio Wijnaldum are carrying knocks but Klopp expects both to be available in time for this match.
Trent Alexander-Arnold will hope to earn a recall at right-back after dropping to the bench against the Terriers, while Roberto Firmino will also return.
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