Virgil van Dijk returns to Southampton for the first time since his £75m move to Liverpool when the sides meet on Sunday, live on Sky Sports Premier League.
If the Saints fail to win, Mauricio Pellegrino's side will equal a club record of seven home Premier League games without victory.
Pellegrino made 13 appearances for the Reds under Rafa Benitez in 2005, before serving as his assistant at Anfield between 2008-2010.
The Saints' win at West Brom last week was their first in 13 Premier League games and they could give record-signing Guido Carrillo his first home start for the visit of Liverpool.
Van Dijk is the latest of six players to move from St Mary's to Anfield since June 2014, for a combined total of £172.5 million, but his arrival has coincided with a spate of late goals conceded by the Merseysiders.
Harry Kane's 95th-minute penalty in a 2-2 draw with Spurs last Sunday was the fifth they had shipped from the 80th minute onwards since January 1, more than any other team in the Premier League.
Southampton manager Mauricio Pellegrino reported no fresh injury problems ahead of Sunday's Premier League match against Liverpool.
Striker Manolo Gabbiadini had been carrying a hip problem last weekend against West Brom, where the Italian was an unused substitute in the 3-2 away win.
Charlie Austin, though, remains out as the forward continues to recover from a hamstring injury.
Defenders Ragnar Klavan and Alberto Moreno have recovered from muscle injuries to take their places in the squad.
Right-back Joe Gomez is unlikely to feature because of a minor knee problem while midfielder Adam Lallana returns after a thigh problem.
| Posted: at | |
TRENDING GISTS 
Nigerian Tenant Discovers Landlord With Wife & Daughter, Sparks Outrage Online (Video)
Popular Gospel Singer, Morenikeji Adeleke, aka Egbin Orun is Dead
I Need Of Electric Car Charger in Naija - Davido Says After Arrival of His 2024 Rolls Royce Spectre
16yr Old Nigerian-born Striker, Martin Obi Scores 7 Goals as Arsenal Trashes Norwich City 9-0
Benin Kingdom Suspends Five Functionaries For ‘Unauthorised’ Visit To Ooni Of Ife
HAPPENING NOW! Death Recorded As Gas Explosion Rocks Abeokuta, Ogun State