Dutch midfielder Wesley Sneijder grabbed the only goal of the game in the sixth minute as his low free-kick found its way through the CSKA wall and beyond goalkeeper Igor Akinfeev.
Things got worse for the hosts when they had substitute Chidi Odiah sent off early in the second half and Inter were comfortably able to repel any pressure from their hosts and coast in the last four.
Overhauling their first-leg deficit always looked like being a tough task for the home side, given the way they were completely outplayed at the San Siro last week and the absence of key midfielder Yevgeny Aldonin and Milos Krasic through suspension.
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