Manchester City will monitor Benjamin Mendy, who has sat out the last two games after suffering a swollen knee on his comeback from injury.
Captain Vincent Kompany will miss an eighth successive match because of a muscle problem.
Arsenal skipper Laurent Koscielny is back in full training after a jaw injury and could feature.
Loan signing Denis Suarez is available for his debut, while Ainsley Maitland-Niles's knee problem will be assessed.
Henrikh Mkhitaryan is nearing a return from a foot injury and will also be monitored, but Sokratis Papastathopoulos, Rob Holding, Hector Bellerin and Danny Welbeck remain out.
The title race isn't over. Liverpool look nervy as leaders. But if City lose this, Pep might have to concede.
On paper, it should be a fourth top-flight win on the spin against Arsenal for the first time in 82 years.
Sergio Aguero has seven goals in 11 games against the Gunners. Guardiola is also unbeaten against Unai Emery, while Arsenal haven't kept a Premier League clean sheet on the road this season.
They also haven't won in 20 away games at established top-six opponents. I can't see that run changing. City won't slip up again.
The Gunners are the only side yet to keep a Premier League clean sheet away from home this season.
They have lost 11 of their last 19 away league games (W5, D3), with their sole clean sheet during this sequence coming in a 1-0 win at Huddersfield in May 2018.
Arsenal are winless in their last 20 league games away to the other sides in the established top six since a 2-0 win at the Etihad Stadium in January 2015, and have lost 10 of their last 12 such fixtures.
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