
Saturday (23/09/2017)
15:00 (WAT)
Saturday's journey to Southampton is followed by flights to Moscow and Lisbon in the Champions League, then across the country for Premier League and League Cup commitments.
Mourinho is expected to use the run to test the depth of his squad before welcoming Tottenham to Old Trafford in five weeks' time.
Southampton could be boosted by a first start of the season for wantaway captain Virgil van Dijk in arguably the club's first real test of the campaign.
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Team news
Manuel Pellegrino is weighing up giving Virgil van Dijk his first start of the season.
The manager told reporters: "We'll decide [on Friday] but every single week, Virgil is important because he is getting better."
Otherwise, Southampton have no fresh injury concerns for their toughest test of the season so far as
Anthony Martial will be hoping to keep his place in the starting XI after being named man of the match against Burton, though Marcus Rashford also impressed.
Luke Shaw also featured but is unlikely to face his former team, while the likes of Paul Pogba, Zlatan Ibrahimovic and Marcos Rojo remain sidelined.
Predicted line-ups
Southampton starting XI: Foster; Soares, Stephens, Yoshida, Bertrand; Romeu, Lemina; Tadic, Davis, Redmond; Gabbiadini
Manchester United starting XI: De Gea; Valencia, Bailly, Jones, Young; Fellaini, Matic; Mata, Mkhitaryan, Rashford; Lukaku
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