Stoke striker Kenwyne Jones is out after picking up a hamstring injury in their midweek Carling Cup tie.
Matthew Upson impressive sufficiently against Spurs in midweek to be pushing for a return though Tony Pulis should recall Jonathan Woodgate.
Manchester United forwards Javier Hernandez and Danny Welbeck will both be pushing for starting slots alongside Wayne Rooney.
Hernandez has made a rapid recovery from the shin injury he sustained in last weekend's win over Chelsea, while Welbeck returned from a hamstring problem in the midweek Carling Cup success at Leeds.
Chris Smalling (groin) is a doubt, but fellow England defender Rio Ferdinand is set to return from a calf injury.
Stoke (Probable, 4-4-2): Begovic; Huth, Shawcross, Woodgate, Wilson; Walters, Delap, Whitehead, Etherington; Jerome, Crouch.
Out: Fuller (Achilles), Higginbotham (knee).
United (Probable, 4-4-1-1): De Gea; Jones, Evans, Ferdinand, Evra; Park, Carrick, Fletcher, Young; Rooney; Hernandez.
Out: Smalling (calf), Rafael (shoulder), Cleverely (ankle), Vidic (knee).
Tests: Ferdinand (hamstring), Welbeck (hamstring).
Referee: Peter Walton (Matches 3, R1 Y16)
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